Scarano Wellerson Rodrigo, Cordeiro Renato Simões, Góes Rejane Maira, Carvalho Hernandes F, Taboga Sebastião Roberto
Department of Cell Biology, UNICAMP, Campinas, São Paulo, Brazil.
Cell Biol Int. 2005 Sep;29(9):778-84. doi: 10.1016/j.cellbi.2005.05.003.
Estrogen seems to have an essential role in the fibromuscular growth characteristic of benign prostatic hyperplasia (BPH). This paper describes the effects of chronic estradiol treatment on Guinea pig prostatic stroma at different ages. Tissues from experimental animals were studied by histological and histochemical procedures, morphometric-stereological analysis and transmission electron microscopy (TEM). Marked fibromuscular hypertrophy was observed after estradiol treatment in animals of pre-pubertal and adult ages. Increases in the density and thickness of the collagen and elastic fibers were observed by histochemistry. TEM revealed wide distributions of collagen fibrils and large elastic fibers adjacent to the epithelial basal lamina and between the stromal cells, establishing contacts between them. These results indicate that the Guinea pig prostate simulates the stromal modifications observed in BPH in some aged animals after estrogen treatment at different ages, making it a good model for this disease.
雌激素似乎在良性前列腺增生（BPH）的纤维肌肉生长特性中起着至关重要的作用。本文描述了慢性雌二醇治疗对不同年龄豚鼠前列腺基质的影响。通过组织学和组织化学程序、形态计量学-体视学分析以及透射电子显微镜（TEM）对实验动物的组织进行了研究。在青春期前和成年期动物接受雌二醇治疗后，观察到明显的纤维肌肉肥大。通过组织化学观察到胶原蛋白和弹性纤维的密度和厚度增加。透射电子显微镜显示，胶原纤维广泛分布，大的弹性纤维位于上皮基底层附近以及基质细胞之间，并在它们之间建立了联系。这些结果表明，豚鼠前列腺模拟了一些老年动物在不同年龄接受雌激素治疗后在BPH中观察到的基质变化，使其成为这种疾病的良好模型。
