Wilson Annette, He Fengtian, Li Jiang, Ma Zheng, Pitt Bruce, Li Song
Department of Environmental and Occupational Health Graduate School of Public Health, School of Pharmacy, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA.
Adv Genet. 2005;54:21-41. doi: 10.1016/S0065-2660(05)54002-1.
Functional oligodeoxynucleotides (ODN) such as antisense ODN (AS-ODN) show promise as new therapeutics for the treatment of a number of pulmonary diseases. They also hold potential to serve as a research tool for the study of gene function related to lung physiology. The success of their application is largely dependent on the development of an efficient delivery vehicle. This chapter summarizes work toward the development of lipidic vectors for targeted ODN delivery to pulmonary circulation. Recent advancements in the development of novel ODN are also discussed briefly.
功能性寡脱氧核苷酸（ODN），如反义ODN（AS-ODN），有望成为治疗多种肺部疾病的新型疗法。它们也有潜力作为研究与肺生理相关基因功能的研究工具。其应用的成功很大程度上取决于高效递送载体的开发。本章总结了为将靶向ODN递送至肺循环而开发脂质载体的工作。还简要讨论了新型ODN开发的最新进展。
