Vanella A, Sorrenti V, Castorina C, Campisi A, Di Giacomo C, Russo A, Perez-Polo J R
Institute of Biochemistry, University of Catania, Italy.
Int J Dev Neurosci. 1992;10(1):75-80. doi: 10.1016/0736-5748(92)90008-n.
Although the role of oxidant-antioxidant metabolism in total ischemia and reperfusion in the central nervous system and cardiac myocardium have been well studied, less is known about the consequences of partial ischemic episodes. Here we show that reperfusion contributes to free radical formation as judged by conjugated diene formation. Also, antioxidants and Ca++ antagonists were able to reduce free radical formation. These results would suggest that free radical generation following ischemia and reperfusion may result from more than one injury process in cerebral cortex.
尽管氧化-抗氧化代谢在中枢神经系统和心肌的完全缺血及再灌注中的作用已得到充分研究，但对于部分缺血发作的后果却知之甚少。在此我们表明，根据共轭二烯的形成判断，再灌注会促使自由基形成。此外，抗氧化剂和钙离子拮抗剂能够减少自由基的形成。这些结果表明，缺血和再灌注后自由基的产生可能源于大脑皮层中不止一种损伤过程。
