广泛气胸、纵隔气肿及手术性气肿作为博来霉素治疗的并发症

Extensive pneumothorax, pneumomediastinum and surgical emphysema as a complication of bleomycin therapy.

作者信息

Jain Tarun P, Thulkar Sanjay, Saha Sanchita, Bakhshi Sameer, Dominic Joseph

机构信息

Department of Radiology, All India Institute of Medical Sciences, New Delhi, 110029, India.

出版信息

Pediatr Radiol. 2005 Dec;35(12):1227-9. doi: 10.1007/s00247-005-1555-y. Epub 2005 Aug 12.

DOI:10.1007/s00247-005-1555-y

PMID:16096827

Abstract

Bleomycin is a commonly used chemotherapeutic agent and one of the commonest cytotoxic drugs leading to pulmonary parenchymal damage. It generally leads to interstitial pneumonitis and fibrosis, hypersensitivity reactions and acute respiratory distress syndrome. We describe an 8-year-old boy who, following prolonged bleomycin therapy, demonstrated extensive air dissection and extrapulmonary air, an unusual and fatal complication.

摘要

博来霉素是一种常用的化疗药物，也是导致肺实质损伤的最常见细胞毒性药物之一。它通常会导致间质性肺炎和纤维化、过敏反应以及急性呼吸窘迫综合征。我们描述了一名8岁男孩，在接受长期博来霉素治疗后，出现了广泛的气体分离和肺外气体，这是一种罕见且致命的并发症。