Hugtenburg Jacqueline G, Griekspoor Judith E, De Boer Ingrid, Heerdink Eibert R, Tso Yung Hwo, Egberts Antoine C G
Department of Pharmacoepidemiology and Pharmacotherapy, Faculty of Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands. J.G.Hugtenburg@ pharm.uu.nl
Pharm World Sci. 2005 Jun;27(3):197-201. doi: 10.1007/s11096-004-2848-1.
With the aim of getting more insight into compliance of children using methylphenidate, we studied the day-to-day use of the drug. In addition, the efficacy and side effects of treatment, stopping, switching to other drugs and the use of additional psychoactive drugs in daily practice were studied.
On the basis of pharmacy records, the use of methylphenidate by 52 children was studied. Two parameters for compliance were calculated. By means of a questionnaire, parents were asked about their children's compliance with the use of methylphenidate as well as about their experience with treatment.
Compliance, use of methylphenidate in weekends and holidays, self-reported efficacy, side effects, stopping and switching to other drugs.
Depending on the parameter calculated, the percentage of children with a good compliance varied from 25 to 47%. About 65% of the children used less or no methylphenidate in the weekends and holidays. Sixty-five percent of the parents reported to pass over a dose once in a while. According to 61% of the parents (n = 28) the efficacy of methylphenidate was good or very good. Nine (33%) of 28 children stopped using methylphenidate. Seven children stopped using the drug because of side-effects or lack of efficacy. Seven children switched to other psychoactive drugs. Fifty-seven percent of all children used additional psychoactive drugs.
The percentage of children having a good compliance calculated on the basis of pharmacy records is rather low. This is partly the result of the decreased use of methylphenidate in the weekends and holidays.
为了更深入了解使用哌甲酯的儿童的依从性，我们研究了该药物的日常使用情况。此外，还研究了治疗的疗效和副作用、停药、换用其他药物以及日常实践中使用其他精神活性药物的情况。
基于药房记录，研究了52名儿童使用哌甲酯的情况。计算了两个依从性参数。通过问卷调查，询问家长孩子使用哌甲酯的依从性以及他们的治疗体验。
依从性、周末和节假日使用哌甲酯的情况、自我报告的疗效、副作用、停药和换用其他药物。
根据所计算的参数，依从性良好的儿童比例在25%至47%之间。约65%的儿童在周末和节假日使用较少或不使用哌甲酯。65%的家长报告偶尔会漏服一剂。61%的家长（n = 28）认为哌甲酯的疗效良好或非常好。28名儿童中有9名（33%）停止使用哌甲酯。7名儿童因副作用或疗效不佳而停药。7名儿童换用了其他精神活性药物。所有儿童中有57%使用了其他精神活性药物。
根据药房记录计算，依从性良好的儿童比例相当低。这部分是由于周末和节假日哌甲酯使用减少所致。
