Li Li, Wu Qiu-Liang, Liu Li-Zhi, Mo Yun-Xian, Xie Chuan-Miao, Zheng Lie, Chen Lin, Wu Pei-Hong
Imaging Diagnosis and Interventional Center, Cancer Center, Sun Yat-Sen University, 651 Dongfeng Road East, Guangzhou 510060, Guangdong Province, China.
World J Gastroenterol. 2005 Aug 21;11(31):4843-7. doi: 10.3748/wjg.v11.i31.4843.
To evaluate the value of CT-guided core-needle biopsy in diagnosis and classification of malignant lymphomas.
From January 1999 to October 2004, CT-guided core-needle biopsies were performed in 80 patients with suspected malignant lymphoma. Biopsies were performed with an 18-20 G biopsy-cut (CR Bard, Inc., Covington, GA, USA) needle driven by a spring-loaded Bard biopsy gun.
A definite diagnosis and accurate histological subtype were obtained in 61 patients with a success rate of 76.25% (61/80). Surgical sampling was performed in 19 patients (23.75%) with non-diagnostic core-needle biopsies. The success rate of CT-guided core-needle biopsy varied with the histopathologic subtypes in our group. The relatively high success rates of core-needle biopsy were noted in diffuse large B-cell non-Hodgkin's lymphoma (NHL, 88.89%) and peripheral T-cell NHL (90%). However, the success rates were relatively low in anaplastic large cell (T/null cell) lymphoma (ALCL, 44.44%) and Hodgkin's disease (HD, 28.57%) in our group.
CT-guided core-needle biopsy is a reliable means of diagnosing and classifying malignant lymphomas, and can be widely applied in the management of patients with suspected malignant lymphoma.
评估CT引导下粗针穿刺活检在恶性淋巴瘤诊断及分类中的价值。
1999年1月至2004年10月，对80例疑似恶性淋巴瘤患者进行CT引导下粗针穿刺活检。活检采用由弹簧驱动的Bard活检枪（美国佐治亚州卡温顿市CR Bard公司生产）及18-20G活检切割针进行。
61例患者获得明确诊断及准确的组织学亚型，成功率为76.25%（61/80）。19例（23.75%）粗针穿刺活检未明确诊断的患者进行了手术取样。在我们的研究组中，CT引导下粗针穿刺活检的成功率因组织病理学亚型而异。弥漫性大B细胞非霍奇金淋巴瘤（NHL，88.89%）和外周T细胞NHL（90%）粗针穿刺活检成功率相对较高。然而，间变性大细胞（T/裸细胞）淋巴瘤（ALCL，44.44%）和霍奇金病（HD，28.57%）在我们组中的成功率相对较低。
CT引导下粗针穿刺活检是诊断和分类恶性淋巴瘤的可靠方法，可广泛应用于疑似恶性淋巴瘤患者的管理。
