伊朗纳哈万德地区乙肝表面抗原阳性家庭成员中乙肝病毒学标志物的家族内患病率

Intra-familial prevalence of hepatitis B virologic markers in HBsAg positive family members in Nahavand, Iran.

作者信息

Mohammad Alizadeh Amir Houshang, Ranjbar Mitra, Ansari Shahin, Alavian Seyed Moayed, Shalmani Hamid Mohaghegh, Hekmat Leila, Zali Mohammad Reza

机构信息

Research Center for Gastroenterology and Liver Disease, Shaheed Beheshti University of Medical Sciences, 7th Floor, Taleghani Hospital, Yaman Street, Evin, Tehran 19857, Iran.

出版信息

World J Gastroenterol. 2005 Aug 21;11(31):4857-60. doi: 10.3748/wjg.v11.i31.4857.

DOI:10.3748/wjg.v11.i31.4857

PMID:16097058

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4398736/

Abstract

AIM

To determine the prevalence of hepatitis B in Nahavand and evaluate the HBsAg positive prevalence in families with a member who was confirmed to have HBV infection.

METHODS

This study was performed in two phases. In the first phase, 1 824 subjects in Nahavand city were selected. The interviewers visited the houses of chosen families to fill the questionnaire and take the blood samples. All subjects signed an informed consent before interviews and blood sampling. The samples were evaluated for HBV virologic markers. In the second phase, 115 HBsAg-positive cases were enrolled and evaluated for HBV virologic markers.

RESULTS

The prevalence of positive HBsAg in Nahavand was 2.3%. The most frequent relatives of index cases were sons and daughters (32.2% and 23.5% respectively). Twelve (11%) of all family members were HBsAg positive. Fifty (56.2%) were isolated HBsAb positive and only one person (2.5%) was isolated HBcAb positive. The higher rates of HBsAg marker were detected in the brothers (1-25%) and fathers (1-12.5%). The infection rate in husbands and wives of index cases was 10%. Only two (16.7%) of all HBsAg-positive participants reported previous HBV vaccination.

CONCLUSION

The prevalence of intra-familial HBV infection is lower in Nahavand of Iran compared to other studies. More attention should be paid to HBV vaccination and risk-lowering activities.

摘要

目的

确定纳哈万德地区乙型肝炎的患病率，并评估有成员确诊感染乙肝病毒（HBV）的家庭中乙肝表面抗原（HBsAg）阳性的患病率。

方法

本研究分两个阶段进行。第一阶段，在纳哈万德市选取了1824名受试者。访谈人员走访选定家庭的住户，填写问卷并采集血样。所有受试者在访谈和血样采集前均签署了知情同意书。对样本进行HBV病毒学标志物评估。第二阶段，纳入115例HBsAg阳性病例并进行HBV病毒学标志物评估。

结果

纳哈万德地区HBsAg阳性患病率为2.3%。索引病例最常见的亲属是儿子和女儿（分别为32.2%和23.5%）。所有家庭成员中有12人（11%）HBsAg呈阳性。50人（56.2%）单独的乙肝表面抗体（HBsAb）呈阳性，只有1人（2.5%）单独的乙肝核心抗体（HBcAb）呈阳性。在兄弟（1 - 25%）和父亲（1 - 12.5%）中检测到较高比例的HBsAg标志物。索引病例的配偶感染率为10%。所有HBsAg阳性参与者中只有两人（16.7%）报告曾接种过乙肝疫苗。