Mansour-Ghanaei Fariborz, Joukar Farahnaz, Yaseri Maryam, Soati Fatemeh, Atrkar-Roushan Zahra
Division of Gastroenterology & Hepatology, Gastrointestinal & Liver Diseases Research Center (GLDRC), Guilan University of Medical Sciences Rasht, Iran.
Int J Mol Epidemiol Genet. 2013 Nov 28;4(4):250-7. eCollection 2013.
The aim of the present study was to determine the intrafamilial spread of HBV in the family members of patients with Hepatitis B in Guilan Province, North of Iran. In a descriptive-comparative study, 156 patients with Hepatitis B, 415 family members of the index cases and 599 age and gender matched people as a control group were enrolled. Blood samples were taken from the participants and were checked for HBs Ag, HBC Ab, HBs Ab, and HBV DNA. Totally 44 (10.6%) of family members and only 1 (0.2%) of control group were HBs Ag positive (P=0.0001, OR=70.92). The overall prevalence in members of the original family was 5.3% (1.2% of the mothers, 2.2% of the brothers, 1.9% of the sisters), in sexual partners it was 1.4%, in offsprings it was 2.4% and in other households it was 1.4%. The mean age of HBs Ag positive family members was 35.3 ± 12.9 years old. Among them 27 (61.4%) were female. Only 8 (18.2%) of all HBsAg-positive reported previous HBV vaccination but just one person had the vaccine titer checked. The present survey indicates that there is a significant difference in the prevalence of Hepatitis B in the general population and family members of Hepatitis B patients and this is an evidence for horizontal transmission of HBV in household contacts.
本研究的目的是确定伊朗北部吉兰省乙型肝炎患者家庭成员中乙肝病毒（HBV）的家庭内传播情况。在一项描述性比较研究中，招募了156例乙型肝炎患者、415例索引病例的家庭成员以及599名年龄和性别匹配的人作为对照组。采集参与者的血样，检测乙肝表面抗原（HBs Ag）、乙肝核心抗体（HBC Ab）、乙肝表面抗体（HBs Ab）和乙肝病毒脱氧核糖核酸（HBV DNA）。共有44名（10.6%）家庭成员乙肝表面抗原呈阳性，而对照组中只有1名（0.2%）呈阳性（P = 0.0001，比值比[OR]=70.92）。原生家庭成员中的总体患病率为5.3%（母亲为1.2%，兄弟为2.2%，姐妹为1.9%），性伴侣中为1.4%，后代中为2.4%，其他家庭成员中为1.4%。乙肝表面抗原阳性家庭成员的平均年龄为35.3±12.9岁。其中27名（61.4%）为女性。在所有乙肝表面抗原阳性者中，只有8名（18.2%）报告曾接种过乙肝疫苗，但只有一人检测了疫苗效价。本次调查表明，普通人群和乙肝患者家庭成员中乙肝的患病率存在显著差异，这是乙肝病毒在家庭接触者中水平传播的证据。
