Park Sung-Joo, Seo Sang-Wan, Choi Ok-Sun, Park Cheung-Seog
Department of Microbiology, College of Medicine, Kyung Hee University #1 Hoegi-dong, Dongdaemun-gu, Seoul 130-701, South Korea.
World J Gastroenterol. 2005 Aug 21;11(31):4883-5. doi: 10.3748/wjg.v11.i31.4883.
Alpha-lipoic acid (ALA) has been used as an antioxidant. The aim of this study was to investigate the effect of alpha-lipoic acid on cholecystokinin (CCK)-octapeptide induced acute pancreatitis in rats.
ALA at 1 mg/kg was intra-peritoneally injected, followed by 75 microg/kg CCK-octapeptide injected thrice subcutaneously after 1, 3, and 5 h. This whole procedure was repeated for 5 d. We checked the pancreatic weight/body weight ratio, the secretion of pro-inflammatory cytokines and the levels of lipase, amylase of serum. Repeated CCK octapeptide treatment resulted in typical laboratory and morphological changes of experimentally induced pancreatitis.
ALA significantly decreased the pancreatic weight/body weight ratio and serum amylase and lipase in CCK octapeptide-induced acute pancreatitis. However, the secretion of IL-1beta, IL-6, and TNF-alpha were comparable in CCK octapeptide-induced acute pancreatitis.
ALA may have a protective effect against CCK octapeptide-induced acute pancreatitis.
α-硫辛酸（ALA）已被用作抗氧化剂。本研究旨在探讨α-硫辛酸对大鼠胆囊收缩素（CCK）-八肽诱导的急性胰腺炎的影响。
腹腔注射1mg/kg的ALA，然后在1、3和5小时后皮下注射75μg/kg的CCK-八肽，共注射三次。整个过程重复5天。我们检测了胰腺重量/体重比、促炎细胞因子的分泌以及血清脂肪酶、淀粉酶水平。重复CCK八肽治疗导致实验性诱导胰腺炎出现典型的实验室和形态学变化。
在CCK八肽诱导的急性胰腺炎中，ALA显著降低了胰腺重量/体重比以及血清淀粉酶和脂肪酶水平。然而，在CCK八肽诱导的急性胰腺炎中，IL-1β、IL-6和TNF-α的分泌水平相当。
ALA可能对CCK八肽诱导的急性胰腺炎具有保护作用。
