3-羟基-3-甲基戊二酰辅酶A（HMG-CoA）还原酶抑制剂洛伐他汀（他汀类药物）可改善大鼠胆囊收缩素诱导的急性胰腺炎。

The 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor, lovastatin (statin) ameliorates CCK-induced acute pancreatitis in rats.

作者信息

Choi Ok-Sun, Park Sung-Joo, Seo Sang-Wan, Park Cheung-Seog, Cho Jeong-Je, Ahn Hyun-Jong

机构信息

Department of Microbiology, College of Medicine, Kyung Hee University, #1 Hoegi-dong, Dongdaemun-gu, Seoul 130-701, Korea.

出版信息

Biol Pharm Bull. 2005 Aug;28(8):1394-7. doi: 10.1248/bpb.28.1394.

DOI:10.1248/bpb.28.1394

PMID:16079481

Abstract

Statin, 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor, has an anti-inflammatory effect. The aim of this study was to investigate the effect of Lovastatin (statin) on the cholecystokinin-octapeptide (CCK)-induced acute pancreatitis in rats. In statin treated group, the pancreas weight/body weight (pw/bw) ratio in CCK-induced acute pancreatitis was significantly lower than DMSO-treated group. Statin also increased the pancreatic level of HSP 60. Additionally, the secretions of IL-1beta, TNF-alpha and IL-6 and the lipase levels were decreased in statin treated group. These results suggest that statin may play an important role in mitigating the progression of the inflammatory reactions during acute pancreatitis.

摘要

他汀类药物，即3-羟基-3-甲基戊二酰辅酶A（HMG-CoA）还原酶抑制剂，具有抗炎作用。本研究旨在探讨洛伐他汀（他汀类药物）对大鼠胆囊收缩素八肽（CCK）诱导的急性胰腺炎的影响。在他汀类药物治疗组中，CCK诱导的急性胰腺炎大鼠的胰腺重量/体重（pw/bw）比值显著低于二甲基亚砜（DMSO）治疗组。他汀类药物还提高了胰腺中热休克蛋白60（HSP 60）的水平。此外，他汀类药物治疗组中白细胞介素-1β（IL-1β）、肿瘤坏死因子-α（TNF-α）和白细胞介素-6的分泌以及脂肪酶水平均降低。这些结果表明，他汀类药物可能在减轻急性胰腺炎期间炎症反应的进展中发挥重要作用。