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验证片:START试验中乳腺癌患者每日及每周摆位重复性的研究

Verification films: a study of the daily and weekly reproducibility of breast patient set-up in the START trial.

作者信息

Venables K, Miles E A, Hoskin P J, Aird E G A

机构信息

Marie Curie Research Wing, Mount Vernon Hospital, Northwood, Middlesex, UK.

出版信息

Clin Oncol (R Coll Radiol). 2005 Aug;17(5):337-42. doi: 10.1016/j.clon.2005.03.006.

Abstract

AIMS

Verification of patient position in radiotherapy by the use of portal images is a current practice in most radiotherapy departments. All patients within the Standardisation of Breast Radiotherapy Trial (START) were required to have on-treatment verification images. Measurements of maximum lung and breast depth from these were used to provide details for the case-report forms. This study was undertaken to validate these measurements, assess the reproducibility of patients' set-up within the START trial and to compare reproducibility on a day-to-day basis with reproducibility over a longer period. Analysis also included a subjective assessment of image quality.

MATERIALS AND METHODS

Fifty-three patients from 29 departments were studied. Some centres used electronic portal imaging and others used film. Where film verification was the method of choice, information was collected about the type of film and cassette used.

RESULTS

The correlation coefficients for inter- and intra-observer variability of breast and lung depth were 0.99. Comparing maximum breast depth on weekly and daily images, the median per cent standard deviation of breast depth was 4% and 3%, respectively. The mean standard deviation of breast depth for all patients, which gives an indication of the individual patient variability, was 5.5 +/- 2.2 mm for weekly and 3.9 +/- 1.5 mm for daily measurements. For lung depth, mean standard deviation was 6.8 +/- 2.5 mm for weekly and 6.8 +/- 2.8 mm for daily measurements. Images taken using Kodak X-omat V film were inferior to those taken with films in corresponding cassettes.

CONCLUSION

Differences between lung depth measured in simulator and on the treatment unit were evident for many patients. There was little difference in the standard deviations of breast and lung depth for daily and weekly verification films on the treatment machine.

摘要

目的

利用射野图像来验证放射治疗中患者的体位是大多数放射治疗科室目前的做法。乳腺癌放射治疗标准化试验(START)中的所有患者都需要有治疗期间的验证图像。通过这些图像测量肺部和乳房的最大深度,为病例报告表提供详细信息。本研究旨在验证这些测量结果,评估START试验中患者摆位的可重复性,并比较日常可重复性与较长时间段内的可重复性。分析还包括对图像质量的主观评估。

材料与方法

对来自29个科室的53名患者进行了研究。一些中心使用电子射野成像,另一些则使用胶片。如果选择胶片验证作为方法,则收集所使用的胶片类型和暗盒的信息。

结果

乳房和肺部深度的观察者间和观察者内变异性的相关系数为0.99。比较每周和每日图像上的乳房最大深度,乳房深度的标准偏差中位数分别为4%和3%。所有患者乳房深度的平均标准偏差(可表明个体患者的变异性),每周测量为5.5±2.2毫米,每日测量为3.9±1.5毫米。对于肺部深度,每周测量的平均标准偏差为6.8±2.5毫米,每日测量为6.8±2.8毫米。使用柯达X-omat V胶片拍摄的图像不如使用相应暗盒中的胶片拍摄的图像。

结论

对于许多患者来说,模拟定位仪测量的肺部深度与治疗设备上测量的肺部深度之间存在明显差异。治疗机上每日和每周验证胶片的乳房和肺部深度标准偏差差异不大。

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