Zhang Yun-ting, Zhang Chun-yan, Zhang Jing, Li Wei
Department of Radiology, General Hospital, Tianjin Medical University, Tianjin 300052, China.
Chin Med J (Engl). 2005 Jul 5;118(13):1059-65.
It is known that the brain structure changes with normal aging. The objective of this study was to quantify the anisotropy and average diffusion coefficient (DCavg) of the brain in normal adults to demonstrate the microstructure changes of brain with aging.
One hundred and six normal adults were examined with diffusion tensor imaging (DTI). The fractional anisotropy (FA), 1-volume ratio (1-VR), relative anisotropy (RA) and average diffusion coefficient (DCavg) of different anatomic sites of brain were measured, correlated with age and compared among three broad age groups.
Except in lentiform nucleus, the anisotropy increased and DCavg decreased with aging. Both anisotropy and DCavg of lentiform nucleus increased with aging. The normal reference values of DTI parameters of normal Chinese adult in major anatomic sites were acquired.
DTI data obtained noninvasively can reflect the microstructural changes with aging. The normal reference values acquired can serve as reference standards in differentiation of brain white matter diseases.
已知脑结构会随着正常衰老而发生变化。本研究的目的是量化正常成年人脑的各向异性和平均扩散系数（DCavg），以证明脑随衰老的微观结构变化。
对106名正常成年人进行扩散张量成像（DTI）检查。测量脑不同解剖部位的分数各向异性（FA）、1体积比（1-VR）、相对各向异性（RA）和平均扩散系数（DCavg），将其与年龄进行相关性分析，并在三个宽泛的年龄组之间进行比较。
除豆状核外，各向异性随衰老增加而DCavg降低。豆状核的各向异性和DCavg均随衰老增加。获得了中国正常成年人主要解剖部位DTI参数的正常参考值。
无创获得的DTI数据可反映随衰老的微观结构变化。所获得的正常参考值可作为脑白质疾病鉴别诊断的参考标准。
