Terasaki Paul I, Cai Junchao
Terasaki Foundation Laboratory, Los Angeles, CA 90064, USA.
Curr Opin Immunol. 2005 Oct;17(5):541-5. doi: 10.1016/j.coi.2005.07.018.
In the two and a half years following our initial paper on the humoral theory of transplantation, many publications have emerged in support of the hypothesis, with no studies in opposition. It is accepted that the role of antibodies is incontrovertible in hyperacute rejection, although what fraction of acute rejection is humoral remains to be determined. A recent large-scale prospective trial showing that transplant patients with antibodies have twice the failure rate as those without antibodies suggests that chronic rejection is also caused by antibodies. Together with serum creatinine, HLA antibodies are, therefore, the best predictor of graft function in kidney patients.
在我们关于移植体液理论的初始论文发表后的两年半时间里，出现了许多支持该假说的出版物，没有反对的研究。虽然急性排斥反应中抗体的作用在超急性排斥反应中是无可争议的，但急性排斥反应中体液因素所占的比例仍有待确定。最近一项大规模前瞻性试验表明，有抗体的移植患者的失败率是没有抗体患者的两倍，这表明慢性排斥反应也是由抗体引起的。因此，与血清肌酐一起，HLA抗体是肾病患者移植肾功能的最佳预测指标。
