Stenn Kurt S, Cotsarelis George
Aderans Research Institute, 3401 Market Street, Philadelphia, Pennsylvania 19104, USA.
Curr Opin Biotechnol. 2005 Oct;16(5):493-7. doi: 10.1016/j.copbio.2005.08.002.
Recent advances in epithelial stem cell biology have resulted in the isolation of hair follicle stem cells, which generate hair follicles when injected into immunodeficient mice. These isolated hair follicle epithelial stem cells must be combined with 'inductive' dermal cells to produce new hair follicles. The advent of techniques for cultivating inductive dermal cells and competent epithelial stem cells creates the opportunity to bioengineer hair follicles for the treatment of hair loss.
上皮干细胞生物学的最新进展已实现毛囊干细胞的分离，将其注入免疫缺陷小鼠体内时可生成毛囊。这些分离出的毛囊上皮干细胞必须与“诱导性”真皮细胞结合才能产生新的毛囊。培养诱导性真皮细胞和有能力的上皮干细胞技术的出现，为生物工程制造用于治疗脱发的毛囊创造了机会。
