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胆囊收缩素四肽在惊恐障碍中的作用复制：临床与行为学发现

Replication of action of cholecystokinin tetrapeptide in panic disorder: clinical and behavioral findings.

作者信息

Bradwejn J, Koszycki D, Payeur R, Bourin M, Borthwick H

机构信息

Division of Psychopharmacology, St. Mary's Hospital Center, Montreal, PQ, Canada.

出版信息

Am J Psychiatry. 1992 Jul;149(7):962-4. doi: 10.1176/ajp.149.7.962.

DOI:10.1176/ajp.149.7.962
PMID:1609879
Abstract

Eleven patients with panic disorder were challenged with cholecystokinin tetrapeptide (CCK-4) on two occasions. The effects of CCK-4 were consistent except symptom onset was more rapid with the second injection. Demonstrating that the effects of CCK-4 are reproducible in panic patients opens the doors for studies of the effects of drug treatment on CCK-4-induced panic.

摘要

11名恐慌症患者分两次接受了四肽胆囊收缩素（CCK - 4）激发试验。CCK - 4的效果是一致的，只是第二次注射时症状出现得更快。证明CCK - 4在恐慌症患者中的效果具有可重复性，为研究药物治疗对CCK - 4诱发恐慌的影响打开了大门。

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Replication of action of cholecystokinin tetrapeptide in panic disorder: clinical and behavioral findings.胆囊收缩素四肽在惊恐障碍中的作用复制：临床与行为学发现
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The Deakin/Graeff hypothesis: focus on serotonergic inhibition of panic.迪肯/格雷夫假说：关注5-羟色胺对惊恐的抑制作用。
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Evaluation of the CCK-4 model as a challenge paradigm in a population of healthy volunteers within a proof-of-concept study.在一项概念验证研究中，对健康志愿者群体中作为激发范式的CCK-4模型进行评估。
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The cholecystokinin-B receptor antagonist CI-988 failed to affect CCK-4 induced symptoms in panic disorder patients.
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