关于胆囊收缩素在惊恐障碍中作用的神经生物学研究。
Neurobiological investigations into the role of cholecystokinin in panic disorder.
作者信息
Bradwejn J
机构信息
Department of Psychiatry, McGill University, St. Mary's Hospital, Montreal, Quebec, Canada.
出版信息
J Psychiatry Neurosci. 1993 Jul;18(4):178-88.
Abstract
Cholecystokinin (CCK) is a neurotransmitter found in high density in the brains of mammals. Microiontophoretic studies showing that benzodiazepines selectively antagonized CCK-induced excitation of rat hippocampal neurons have led to the hypothesis that CCK is an anxiogenic peptide. The hypothesis was supported by demonstrations that CCK-tetrapeptide (CCK4) induces panic attacks in humans. This paper reviews phases of investigations which studied the validity of CCK4 as a panicogenic agent and research strategies for the study of panic disorder using CCK4 as an investigative tool.
摘要
胆囊收缩素（CCK）是一种在哺乳动物大脑中高密度存在的神经递质。微离子电泳研究表明，苯二氮䓬类药物可选择性拮抗CCK诱导的大鼠海马神经元兴奋，这导致了一种假说，即CCK是一种致焦虑肽。CCK四肽（CCK4）可诱发人类恐慌发作的证据支持了这一假说。本文回顾了研究CCK4作为致恐慌剂有效性的各个研究阶段，以及使用CCK4作为研究工具来研究恐慌症的研究策略。
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