奎宁治疗后输入性恶性疟复发：与苯妥英钠潜在的药物相互作用。

Recrudescence of imported falciparum malaria after quinine therapy: potential drug interaction with phenytoin.

作者信息

Fabre C, Criddle J, Nolder D, Klein J L

机构信息

Department of Paediatric Emergency Medicine, Guy's and St Thomas' NHS Foundation Trust, Lambeth Wing, St Thomas' Hospital, London SE1 7EH, UK.

出版信息

Trans R Soc Trop Med Hyg. 2005 Nov;99(11):871-3. doi: 10.1016/j.trstmh.2005.06.009.

DOI:10.1016/j.trstmh.2005.06.009

Abstract

Quinine remains a reliable treatment for falciparum malaria in most parts of the world. We report recrudescence of imported Plasmodium falciparum malaria following quinine treatment in the context of concurrent phenytoin use. Supported by a subtherapeutic quinine level, we hypothesise that a drug interaction with phenytoin may compromise the efficacy of quinine in the treatment of malaria.

摘要

在世界大部分地区，奎宁仍然是治疗恶性疟的可靠药物。我们报告了在同时使用苯妥英钠的情况下，奎宁治疗后输入性恶性疟原虫疟疾复发的病例。在奎宁水平低于治疗剂量的支持下，我们推测与苯妥英钠的药物相互作用可能会损害奎宁治疗疟疾的疗效。

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