因血浆奎宁浓度异常低导致的重症疟疾早期治疗失败。
Early treatment failure in severe malaria resulting from abnormally low plasma quinine concentrations.
作者信息
Newton Paul N, Ward Steven, Angus Brian J, Chierakul Wirongrong, Dondorp Arjen, Ruangveerayuth Ronnatrai, Silamut Kamolrat, Teerapong Pramote, Suputtamongkol Yupin, Looareesuwan Sornchai, White Nicholas J
机构信息
Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand.
出版信息
Trans R Soc Trop Med Hyg. 2006 Feb;100(2):184-6. doi: 10.1016/j.trstmh.2005.01.008. Epub 2005 Nov 10.
A patient admitted with severe Plasmodium falciparum malaria in western Thailand had an early treatment failure with quinine, despite full dosing. Plasma quinine concentrations were subtherapeutic. Abnormal quinine pharmacokinetics may explain sporadic reports of quinine treatment failures in severe malaria.
一名在泰国西部因严重恶性疟原虫疟疾入院的患者，尽管已足量给药，但使用奎宁治疗仍早期失败。血浆奎宁浓度低于治疗水平。异常的奎宁药代动力学可能解释了重症疟疾中奎宁治疗失败的零星报告。
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