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[突尼斯血友病患者中的血液传播病毒感染]

[Blood-transmitted viral infections among haemophiliacs in Tunisia].

作者信息

Langar H, Triki H, Gouider E, Bahri O, Djebbi A, Sadraoui A, Hafsia A, Hafsia R

机构信息

Laboratoire de virologie clinique, institut Pasteur de Tunis, Tunisie.

出版信息

Transfus Clin Biol. 2005 Oct;12(4):301-5. doi: 10.1016/j.tracli.2005.07.001. Epub 2005 Aug 11.

Abstract

In this work, we proposed to evaluate prevalences of hepatitis B and C viruses and Parvovirus B19 among 70 Tunisian haemophiliacs treated with clotting factors imported from Europe and/or locally produced cryoprecipitate; among them 6 (8.6%) are known HIV positive patients. HBs antigen, anti-HBc antibodies and anti-Parvovirus B19 antibodies were detected in 7.1%, 52.9% and 91.8%, respectively. HCV prevalence, defined as positive ELISA with positive Immunoblot and/or PCR was 50.0%. Prevalences of these viral infections in haemophiliacs are higher than prevalences detected among general population and in the control group of the study. HCV infection is less frequent in haemophiliacs born after 1985, the year of introduction of the inactivation procedures in the production of coagulation factors concentrates; it decreases more considerably after 1994, date of introduction of systematic screening of HCV among blood donors. In contrast, despite the inactivation of the factors concentrates and the systematic screening of the blood donations against HBs antigen, since 1973, the risk of HBV infection contamination remains high in the Tunisian haemophiliacs. The introduction in 1995 of hepatitis B vaccination in the national schedule of new-born vaccination may resolve in the future the problem of HBV infection in haemophiliacs and in the other categories of the Tunisian population.

摘要

在这项研究中,我们提议评估70名接受从欧洲进口的凝血因子和/或本地生产的冷沉淀治疗的突尼斯血友病患者中乙型肝炎病毒、丙型肝炎病毒和细小病毒B19的感染率;其中6名(8.6%)为已知的HIV阳性患者。HBs抗原、抗-HBc抗体和抗细小病毒B19抗体的检测率分别为7.1%、52.9%和91.8%。HCV感染率(定义为ELISA阳性且免疫印迹和/或PCR阳性)为50.0%。血友病患者中这些病毒感染的感染率高于普通人群和该研究对照组中检测到的感染率。1985年(即凝血因子浓缩物生产中引入灭活程序的年份)之后出生的血友病患者中HCV感染较少见;1994年(即开始对献血者进行HCV系统筛查的日期)之后,感染率下降更为显著。相比之下,尽管自1973年以来凝血因子浓缩物已灭活且对献血进行了针对HBs抗原的系统筛查,但突尼斯血友病患者中HBV感染的风险仍然很高。1995年在国家新生儿疫苗接种计划中引入乙肝疫苗接种,未来可能会解决血友病患者及突尼斯其他人群中的HBV感染问题。

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