Sánchez-Alemán Miguel A, Conde-Glez Carlos J, Gayet Cecilia, García-Cisneros Santa, Uribe-Salas Felipe
Center for Research in Infectious Diseases, National Institute of Public Health, Cuernavaca, Morelos, Mexico.
Arch Med Res. 2005 Sep-Oct;36(5):574-80. doi: 10.1016/j.arcmed.2005.03.028.
Given the relevance of HSV-2 infection in youth, the aim of this study was to determine the seroprevalence of HSV-2 in college students in Cuernavaca, Mexico, as well as the sociodemographic and sexual behavioral characteristics associated with this infection.
A cross-sectional study was carried out using convenience sampling with consenting students of both genders. Students answered a questionnaire and provided a blood sample to detect antibodies to HSV-2 by Western blot. To establish the magnitude of the association between the prevalence of HSV-2 infection and the selected risk factors, we estimated prevalence odds ratios by performing logistic analyses of these results
Overall seroprevalence of HSV-2 was 5.9% (20/340; CI(95%) 3.7-8.9), 7.0% (14/200; CI(95%) 3.9-11.5) for women and 4.3% (6/140; CI(95%) 1.6-9.1) for men. HSV-2 infection was independently associated with female sex (POR=5.3, CI(95%) 1.4-19.7), age (26 years and over, POR=4.7, CI(95%) 1.0-22.2), number of sexual partners over the last year (two or more partners POR=4.1, CI(95%) 1.2-14.2), a history of genital ulcers (POR=6.1, CI(95%) 1.9-19.8), and having been paid for sex (POR=21.4, CI(95%) 1.0-447.5).
The frequency of HSV-2 infection among these students was lower than in other Mexican populations who have high-risk sexual behavior. However, there was a subgroup of participants identified as having high-risk sexual behavior. These individuals could, therefore, be prone to acquiring and transmitting HSV-2 infection and represent the target group for whom preventive interventions against HSV-2 and other STIs might be developed.
鉴于单纯疱疹病毒2型（HSV-2）感染在青年人群中的相关性，本研究旨在确定墨西哥库埃纳瓦卡大学生中HSV-2的血清流行率，以及与该感染相关的社会人口学和性行为特征。
采用便利抽样对同意参与的男女学生进行横断面研究。学生们回答了一份问卷，并提供血样，通过蛋白质印迹法检测HSV-2抗体。为确定HSV-2感染率与选定风险因素之间关联的强度，我们通过对这些结果进行逻辑分析来估计患病比值比。
HSV-2的总体血清流行率为5.9%（20/340；95%置信区间3.7 - 8.9），女性为7.0%（14/200；95%置信区间3.9 - 11.5），男性为4.3%（6/140；95%置信区间1.6 - 9.1）。HSV-2感染与女性性别（患病比值比=5.3，95%置信区间1.4 - 19.7）、年龄（26岁及以上，患病比值比=4.7，95%置信区间1.0 - 22.2）、过去一年性伴侣数量（两个或更多伴侣，患病比值比=4.1，95%置信区间1.2 - 14.2）、生殖器溃疡病史（患病比值比=6.1，95%置信区间1.9 - 19.8）以及曾有过性交易（患病比值比=21.4，95%置信区间1.0 - 447.5）独立相关。
这些学生中HSV-2感染的频率低于其他有高危性行为的墨西哥人群。然而，有一部分参与者被确定为有高危性行为。因此，这些人可能容易感染和传播HSV-2，是针对HSV-2和其他性传播感染制定预防干预措施的目标群体。
