6个国家中年女性2型单纯疱疹病毒的型特异性血清流行率及相关危险因素：国际癌症研究机构多中心研究

Type-specific seroprevalence of herpes simplex virus type 2 and associated risk factors in middle-aged women from 6 countries: the IARC multicentric study.

作者信息

Patnaik Padmaja, Herrero Rolando, Morrow R Ashley, Munoz Nubia, Bosch F Xavier, Bayo Sine, El Gueddari Brahim, Caceres Eduardo, Chichareon Saibua B, Castellsague Xavier, Meijer Chris J L M, Snijders Peter J F, Smith Jennifer S

机构信息

Department of Epidemiology, CB# 7435, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7435, USA.

出版信息

Sex Transm Dis. 2007 Dec;34(12):1019-24.

PMID:18080353

Abstract

GOAL

To determine type-specific seroprevalence of herpes simplex viruses (HSV-1 and HSV-2) and HSV-2 risk factors.

STUDY DESIGN

Six-hundred fifty eight middle-aged control women (hospital-based in 4 of 6 countries) from a multicenter cervical cancer case-control study participated from 1985 to 1997. Type-specific serum IgG antibodies against HSV-1 and HSV-2 were detected with Western Blot.

RESULTS

HSV-1 seroprevalence was 89% to 100% everywhere except Thailand (51%). HSV-2 seroprevalence ranged from 9% (Spain) to 57% (Colombia), and was independently associated with having >or=2 lifetime sexual partners overall [Odds ratio (OR), 2.1; 95% confidence interval (CI) 2.5-3.1], and in Morocco (OR, 2.7; 95% CI, 1.2-6.1) and Thailand (OR, 4.4; 95% CI, 1.3-15.4), and with being unmarried in Colombia, Peru, Spain, but not significantly in Mali. Women whose male partner's sexual debut was <or=17 years had a higher HSV-2 risk (OR, 4.3 95% CI, 1.3-13.7).

CONCLUSIONS

HSV-2 seroprevalence in middle-aged women varied over 4-fold and was associated with riskier sexual behaviors in women and their male partners.

摘要

目的

确定单纯疱疹病毒（HSV-1和HSV-2）的型特异性血清流行率及HSV-2的危险因素。

研究设计

来自一项多中心宫颈癌病例对照研究的658名中年对照女性（6个国家中的4个国家以医院为基础）于1985年至1997年参与研究。采用蛋白质印迹法检测针对HSV-1和HSV-2的型特异性血清IgG抗体。

结果

除泰国（51%）外，各地HSV-1血清流行率为89%至100%。HSV-2血清流行率从9%（西班牙）到57%（哥伦比亚）不等，总体上与一生中拥有≥2个性伴侣独立相关[比值比（OR），2.1；95%置信区间（CI）2.5 - 3.1]，在摩洛哥（OR，2.7；95% CI，1.2 - 6.1）和泰国（OR，4.4；95% CI，1.3 - 15.4）也是如此，在哥伦比亚、秘鲁、西班牙，未婚女性的HSV-2血清流行率也较高，但在马里无显著差异。男性性初次接触年龄≤17岁的女性感染HSV-2的风险更高（OR，4.3；95% CI，1.3 - 13.7）。