In vivo cytogenetic screening for determination of the mutagenic potential of cyclophosphamide.

Among the in vivo cytogenetic tests employed for chemically induced mutagenicity, a recent screening method was selected - the micronucleus test. The micronuclei were investigated, comparatively with chromosome breaks, on the bone marrow of Wistar rats after intraperitoneal administration of different doses of Cyclophosphamide (CY) applied in one or two injections at 24 hrs interval. The good relationship between these two tests was proved in evaluation of cytogenetic risk.