Pucéat Michel, Jaconi Marisa
CNRS FRE2593, CRBM, 1919, route de Mende, 34293 Montpellier, France.
Cell Calcium. 2005 Sep-Oct;38(3-4):383-9. doi: 10.1016/j.ceca.2005.06.016.
A variety of InsP3-dependent Ca2+ signals coded in time, amplitude and space occur during the process of cardiac cell differentiation and heart development. Studies performed in both embryos and embryonic stem cell differentiating in cardiomyocytes have uncovered that Ca2+ regulates multiple steps of these biological processes in vertebrates. These include secretion of cardiogenic factors, cardiac transcriptional cascades and in turn gene expression, myofibrillogenesis and initiation of embryonic pacemaker activity. Evidence is accumulating to foresee Ca2+ as a major second messenger in directing the fate of stem cells and patterning the heart in the embryo.
在心脏细胞分化和心脏发育过程中，会出现各种在时间、幅度和空间上编码的依赖三磷酸肌醇（InsP3）的钙离子信号。在胚胎和分化为心肌细胞的胚胎干细胞中进行的研究发现，钙离子在脊椎动物中调节这些生物过程的多个步骤。这些步骤包括心脏发生因子的分泌、心脏转录级联反应以及随之而来的基因表达、肌原纤维生成和胚胎起搏器活动的启动。越来越多的证据表明，钙离子是指导干细胞命运和胚胎心脏模式形成的主要第二信使。
