《心跳的起源-心肌收缩活动的起源》。
The First Heartbeat-Origin of Cardiac Contractile Activity.
机构信息
Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford OX1 3QX, United Kingdom.
出版信息
Cold Spring Harb Perspect Biol. 2020 Jul 1;12(7):a037135. doi: 10.1101/cshperspect.a037135.
Abstract
The amniote embryonic heart starts as a crescent of mesoderm that transitions through a midline linear heart tube in the course of developing into the four chambered heart. It is unusual in having to contract rhythmically while still undergoing extensive morphogenetic remodeling. Advances in imaging have allowed us to determine when during development this contractile activity starts. In the mouse, focal regions of contractions can be detected as early as the cardiac crescent stage. Calcium transients, required to trigger contraction, can be detected even earlier, prior to contraction. In this review, we outline what is currently known about how this early contractile function is initiated and the impact early contractile function has on cardiac development.
摘要
羊膜动物胚胎心脏起始于新月形中胚层，在发育为四腔心脏的过程中通过中线线性心管过渡。它的独特之处在于，在进行广泛的形态发生重塑的同时还必须有节奏地收缩。成像技术的进步使我们能够确定在发育过程中何时开始这种收缩活动。在小鼠中，早在心脏新月形阶段就可以检测到收缩的局灶区域。甚至在收缩之前，就可以检测到触发收缩所需的钙瞬变。在这篇综述中，我们概述了目前已知的早期收缩功能是如何启动的，以及早期收缩功能对心脏发育的影响。
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