LaFever Leesa, Drummond-Barbosa Daniela
Department of Cell and Developmental Biology, Vanderbilt University Medical Center, 4120B Medical Research Building III, 465 21st Avenue South, Nashville, TN 37232-8240, USA.
Science. 2005 Aug 12;309(5737):1071-3. doi: 10.1126/science.1111410.
Stem cells reside in specialized niches that provide signals required for their maintenance and division. Tissue-extrinsic signals can also modify stem cell activity, although this is poorly understood. Here, we report that neural-derived Drosophila insulin-like peptides (DILPs) directly regulate germline stem cell division rate, demonstrating that signals mediating the ovarian response to nutritional input can modify stem cell activity in a niche-independent manner. We also reveal a crucial direct role of DILPs in controlling germline cyst growth and vitellogenesis.
干细胞存在于特定的微环境中，这些微环境提供维持和分裂所需的信号。组织外部信号也可以改变干细胞的活性，尽管对此了解甚少。在这里，我们报告神经源性果蝇胰岛素样肽（DILPs）直接调节生殖系干细胞的分裂速率，这表明介导卵巢对营养输入反应的信号可以以不依赖微环境的方式改变干细胞活性。我们还揭示了DILPs在控制生殖系囊肿生长和卵黄发生中的关键直接作用。
