Schuenemann Gustavo M, Hockett Mitch E, Edwards J Lannett, Rohrbach Nancy R, Breuel Kevin F, Schrick F Neal
Department of Animal Science, University of Tennessee, Knoxville, TN 37996-4574, USA.
Reprod Biol. 2005 Jul;5(2):137-50.
Two experiments were performed to determine whether administration of ergotamine tartrate altered embryo development (Exp. 1) and uterine competency to establish pregnancy (Exp. 2) in beef cattle. Animals were fed daily either 0 (CON) or 40 mug/kg body weight of ergotamine tartrate (ERGOT). Following a 30-d period on respective diets, animals in Exp. 1 were artificial inseminated at estrus (d = 0) and single embryo recoveries performed on day 7; whereas, animals in Exp. 2 received two frozen-thawed embryos on day 7. As an indicator of ergotamine effects, prolactin was decreased throughout both experiments in ERGOT compared to CON animals (p<0.05). Furthermore, rectal temperature (RT) tended to increase during both experiments in ERGOT compared to CON (p= 0.06). In Exp. 1, embryo recovery (p=0.08) and the percentage of transferable embryos (p=0.09) tended to be greater for CON than for ERGOT. Percentage of embryos that developed to compacted morula or greater was increased for CON compared to ERGOT heifers (p<0.05). In Exp. 2, pregnancy rates of transferred embryos did not differ between treatment groups. Thus, administration of ERGOT to simulate fescue toxicosis altered developmental potential of embryos, but does not appear to affect uterine competency to establish pregnancy.
进行了两项试验，以确定给肉牛施用酒石酸麦角胺是否会改变胚胎发育（试验1）以及子宫建立妊娠的能力（试验2）。动物每天分别饲喂0（对照）或40微克/千克体重的酒石酸麦角胺（ERGOT）。在各自的日粮上饲养30天后，试验1中的动物在发情期（第0天）进行人工授精，并在第7天进行单胚胎回收；而试验2中的动物在第7天接受两个冻融胚胎。作为麦角胺作用的一个指标，与对照动物相比，在整个两个试验中，ERGOT组的催乳素均降低（p<0.05）。此外，与对照相比，在两个试验中，ERGOT组的直肠温度（RT）均有升高的趋势（p = 0.06）。在试验1中，对照的胚胎回收率（p = 0.08）和可移植胚胎的百分比（p = 0.09）均有高于ERGOT组的趋势。与ERGOT组的小母牛相比，对照中发育到致密桑椹胚或更高级别的胚胎百分比有所增加（p<0.05）。在试验2中，各处理组之间移植胚胎的妊娠率没有差异。因此，施用ERGOT以模拟牛茅草中毒会改变胚胎的发育潜力，但似乎不会影响子宫建立妊娠的能力。
