Matsuzaki H, Katsumata S I, Uehara M, Suzuki K, Nakamura K
Department of Nutrition, Junior College of Tokyo University of Agriculture, 1-1-1 Sakuragaoka, Setagaya-ku, Tokyo 156-8502, Japan.
Magnes Res. 2005 Jun;18(2):97-102.
We examined the effects of high calcium (Ca) intake on bone metabolism in magnesium (Mg)-deficient rats. Male Wistar rats were divided into three groups, with each group having a similar mean body weight, and fed a control diet (control group), a Mg-deficient diet (Mg-deficient group) or a Mg-deficient Ca-supplemented diet (Mg-deficient Ca-supplemented group) for 14 d. Femoral Ca content was significantly lower in the Mg-deficient Ca-supplemented group than in the control group and Mg-deficient group. Femoral Mg content was significantly lower in the Mg-deficient group and Mg-deficient Ca-supplemented group than in the control group. Furthermore, femoral Mg content was significantly lower in the Mg-deficient Ca-supplemented group than in the Mg-deficient group. Serum osteocalcin levels (a biochemical marker of bone formation) were significantly lower in the two Mg-deficient groups than in the control group. As a biochemical marker of bone resorption, urinary deoxypyridinoline excretion was significantly higher in the Mg-deficient Ca-supplemented group than in the control group and Mg-deficient group. The results in the present study suggest that high Ca intake had no preventive effect on alteration of bone metabolism in Mg-deficient rats.
我们研究了高钙摄入对镁缺乏大鼠骨代谢的影响。将雄性Wistar大鼠分为三组，每组平均体重相似，分别给予对照饮食（对照组）、缺镁饮食（缺镁组）或缺镁补钙饮食（缺镁补钙组）14天。缺镁补钙组的股骨钙含量显著低于对照组和缺镁组。缺镁组和缺镁补钙组的股骨镁含量显著低于对照组。此外，缺镁补钙组的股骨镁含量显著低于缺镁组。两个缺镁组的血清骨钙素水平（骨形成的生化标志物）显著低于对照组。作为骨吸收的生化标志物，缺镁补钙组的尿脱氧吡啶啉排泄量显著高于对照组和缺镁组。本研究结果表明，高钙摄入对缺镁大鼠骨代谢改变无预防作用。
