膳食补充钙会抑制缺镁大鼠的骨形成。

Dietary calcium supplementation suppresses bone formation in magnesium-deficient rats.

作者信息

Matsuzaki Hiroshi, Miwa Misao

机构信息

Department of Nutrition, Junior College of Tokyo University of Agriculture, 1-1-1 Sakuragaoka, Setagaya-ku, Tokyo 156-8502, Japan.

出版信息

Int J Vitam Nutr Res. 2006 May;76(3):111-6. doi: 10.1024/0300-9831.76.3.111.

DOI:10.1024/0300-9831.76.3.111

PMID:17048189

Abstract

The purpose of this study was to clarify the effects of dietary calcium (Ca) supplementation on bone metabolism of magnesium (Mg)-deficient rats. Male Wistar rats were randomized by weight into three groups, and fed a control diet (control group), a Mg-deficient diet (Mg- group) or a Mg-deficient diet having twice the control Ca concentrations (Mg-2Ca group) for 14 days. Trabecular bone volume was significantly lower in the Mg- and Mg-2Ca groups than in the control group. Trabecular number was also significantly lower in the Mg- and Mg-2Ca groups than in the control group. Mineralizing bone surface, mineral apposition rate (MAR), and surface referent bone formation rate (BFR/BS) were significantly lower in the Mg- and Mg-2Ca groups than in the control group. Furthermore, MAR and BFR/BS were significantly lower in the Mg-2Ca group than in the Mg- group. These results suggest that dietary Ca supplementation suppresses bone formation in Mg-deficient rats.

摘要

本研究的目的是阐明膳食补充钙（Ca）对镁（Mg）缺乏大鼠骨代谢的影响。雄性Wistar大鼠按体重随机分为三组，分别给予对照饮食（对照组）、缺镁饮食（Mg-组）或钙浓度为对照两倍的缺镁饮食（Mg-2Ca组），持续14天。Mg-组和Mg-2Ca组的小梁骨体积显著低于对照组。Mg-组和Mg-2Ca组的小梁数量也显著低于对照组。Mg-组和Mg-2Ca组的矿化骨表面、矿物质沉积率（MAR）和表面参考骨形成率（BFR/BS）显著低于对照组。此外，Mg-2Ca组的MAR和BFR/BS显著低于Mg-组。这些结果表明，膳食补充钙会抑制缺镁大鼠的骨形成。