Szekanecz Zoltán, Koch Alisa E
Division of Rheumatology, Third Department of Medicine, University of Debrecen Medical and Health Sciences Center, Debrecen H-4004, Hungary.
Curr Drug Targets Inflamm Allergy. 2005 Jun;4(3):319-23. doi: 10.2174/1568010054022187.
Endothelial cells are involved in leukocyte extravasation underlying inflammation. A number of adhesion molecules play a role in leukocyte-endothelial interactions. New vessel formation, termed angiogenesis, is also crucial for leukocyte extravasation. The outcome of neovascularization is highly dependent on the balance or imbalance between angiogenic mediators and inhibitors. There have been several attempts to therapeutically interfere with the cellular and molecular mechanisms, such as leukocyte-endothelial cell adhesion and angiogenesis. Most studies have been performed using animal models of various types of inflammation, such as arthritis. In addition, a very limited number of human clinical trials gave promising results. In this review, authors summarize the most relevant information on adhesion molecules, as well as angiogenic and angiostatic agents. In addition, further perspectives of anti-adhesive and anti-angiogenic therapy are also discussed. Specific targeting of pathological endothelial function including adhesion and angiogenesis, may be useful for the future management of various inflammatory diseases.
内皮细胞参与炎症相关的白细胞渗出过程。多种黏附分子在白细胞与内皮细胞的相互作用中发挥作用。新血管形成，即血管生成，对白细胞渗出也至关重要。新血管形成的结果高度依赖于血管生成介质与抑制剂之间的平衡或失衡。已有多项尝试从治疗角度干预细胞和分子机制，如白细胞与内皮细胞的黏附以及血管生成。大多数研究是在各种炎症的动物模型（如关节炎模型）上进行的。此外，仅有极少数的人体临床试验取得了有前景的结果。在这篇综述中，作者总结了关于黏附分子以及血管生成剂和血管生成抑制剂的最相关信息。此外，还讨论了抗黏附治疗和抗血管生成治疗的进一步前景。对包括黏附与血管生成在内的病理性内皮功能进行特异性靶向治疗，可能对未来各种炎症性疾病的治疗有益。
