Cardoso S M, Moreira P I, Agostinho P, Pereira C, Oliveira C R
Center for Neuroscience and Cell Biology and Institute of Biochemistry, Faculty of Medicine of Coimbra, University of Coimbra, 3004-504 Coimbra, Portugal.
Curr Drug Targets CNS Neurol Disord. 2005 Aug;4(4):405-19. doi: 10.2174/1568007054546072.
Parkinson's disease (PD), considered one of the major neurological disorders, is characterized by the loss of dopaminergic neurons in the pars compacta of the substantia nigra and by the presence of intraneuronal cytoplasmic inclusions called Lewy bodies. The causes for degeneration of PD neurons remain unclear, however, recent findings contributed to clarify this issue. This review will discuss the current understanding of the mechanisms underlying Parkinson's disease pathogenesis, focusing on the current and potential therapeutic strategies for human treatment.
帕金森病（PD）被认为是主要的神经疾病之一，其特征是黑质致密部多巴胺能神经元的丧失以及神经元内存在称为路易小体的胞质内含物。然而，PD神经元变性的原因尚不清楚，不过，最近的研究结果有助于阐明这一问题。本综述将讨论目前对帕金森病发病机制的理解，重点关注当前和潜在的人类治疗策略。
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