白癜风患者中超氧化物歧化酶、过氧化氢酶、谷胱甘肽过氧化物酶活性及硝酸盐水平的比较研究
A comparative study of superoxide dismutase, catalase, and glutathione peroxidase activities and nitrate levels in vitiligo patients.
作者信息
Hazneci Ersoy, Karabulut Aysun Bay, Oztürk Cetin, Batçioğlu Kadir, Doğan Gürsoy, Karaca Semsettin, Eşrefoğlu Muammer
机构信息
Department of Dermatology, University of Inonu, Malatya, Turkey.
出版信息
Int J Dermatol. 2005 Aug;44(8):636-40. doi: 10.1111/j.1365-4632.2004.02027.x.
BACKGROUND
Several groups have shown the involvement of oxidative stress in the pathophysiology of vitiligo.
METHODS
In this study, we examined the erythrocyte and plasma activities of glutathione peroxidase and Cu/Zn superoxide dismutase, plasma nitrite/nitrate levels, and erythrocyte catalase activity in 23 vitiligo patients and 25 controls.
RESULTS
The results show that erythrocyte superoxide dismutase activity and plasma nitrite/nitrate levels are high in vitiligo patients.
CONCLUSIONS
Our study confirms that oxidative stress is involved in the pathophysiology of vitiligo, as indicated by the high levels of erythrocyte superoxide dismutase activity and plasma nitrite/nitrate.
背景
多个研究小组已表明氧化应激参与白癜风的病理生理过程。
方法
在本研究中，我们检测了23例白癜风患者和25例对照者的红细胞及血浆中谷胱甘肽过氧化物酶和铜/锌超氧化物歧化酶的活性、血浆亚硝酸盐/硝酸盐水平以及红细胞过氧化氢酶活性。
结果
结果显示白癜风患者的红细胞超氧化物歧化酶活性及血浆亚硝酸盐/硝酸盐水平较高。
结论
我们的研究证实，红细胞超氧化物歧化酶活性及血浆亚硝酸盐/硝酸盐水平升高表明氧化应激参与白癜风的病理生理过程。
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