给予铅或镉后大鼠肝脏和肾脏中谷胱甘肽-S-转移酶的活性。
Activity of glutathione-S-transferase in rat liver and kidneys after administration of lead or cadmium.
作者信息
Planas-Bohne F, Elizalde M
机构信息
Kernforschungszentrum Karlsruhe, Institut für Genetik und Toxikologie, Germany.
出版信息
Arch Toxicol. 1992;66(5):365-7. doi: 10.1007/BF01973633.
The influence of an acute dose of lead nitrate or cadmium chloride on the activity of glutathione-S-transferase (GST) was investigated in rats. CdCl2 (10 mumol/kg) did not influence the enzyme activity in either organ. In contrast Pb(NO3)2 (100 mumol/kg) caused a significant increase of GST activity in both organs. SDS polyacrylamide gel electrophoresis (SDS-PAGE) showed that in liver the activity enhancement is due mainly to the induction of the isoenzyme GST 7-7, while in the kidneys the activity of all the isoenzymes is increased.
研究了急性剂量的硝酸铅或氯化镉对大鼠谷胱甘肽 - S - 转移酶（GST）活性的影响。氯化镉（10 μmol/kg）对两个器官中的该酶活性均无影响。相比之下，硝酸铅（100 μmol/kg）导致两个器官中GST活性显著增加。十二烷基硫酸钠 - 聚丙烯酰胺凝胶电泳（SDS - PAGE）表明，在肝脏中活性增强主要归因于同工酶GST 7 - 7的诱导，而在肾脏中所有同工酶活性均增加。
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