Roomi M W, Columbano A, Ledda-Columbano G M, Sarma D S
Toxicol Pathol. 1987;15(2):202-5. doi: 10.1177/019262338701500213.
The administration of a single dose of lead nitrate to male Wistar rats caused an increase of a polypeptide in the liver cytosol that cross reacted with the anti-rat antibody of the placental form of glutathione S-transferase (GST-P). GST-P appeared when doses of lead that induced liver cell proliferation were given (5 and 10 micromoles/100 g of body weight). Recently, it has been shown that rat hepatic nodules also exhibited an increased content of the placental form of GST-P. The induction of GST-P by lead together with other biochemical effects exerted in the liver by this metal, suggests that some chemicals may induce in rat liver a biochemical pattern similar, in some aspects, to that exhibited by carcinogen-induced hepatocyte nodules.
给雄性Wistar大鼠单次注射硝酸铅，会导致肝细胞溶质中的一种多肽增加，该多肽与谷胱甘肽S - 转移酶（GST - P）胎盘形式的抗大鼠抗体发生交叉反应。当给予诱导肝细胞增殖的铅剂量（5和10微摩尔/100克体重）时，GST - P出现。最近研究表明，大鼠肝结节中GST - P胎盘形式的含量也有所增加。铅对GST - P的诱导作用以及这种金属在肝脏中产生的其他生化效应表明，某些化学物质可能在大鼠肝脏中诱导出一种在某些方面与致癌物诱导的肝细胞结节所呈现的生化模式相似的模式。
