Tang Jianming, Shao Wenshuo, Dorak M Tevfik, Li Yufeng, Miike Rei, Lobashevsky Elena, Wiencke John K, Wrensch Margaret, Kaslow Richard A, Cobbs Charles S
Department of Medicine, University of Alabama at Birmingham, 1665 University Boulevard, RPHB Room 220A, Birmingham, AL 35294-0022, USA.
Cancer Epidemiol Biomarkers Prev. 2005 Aug;14(8):2040-4. doi: 10.1158/1055-9965.EPI-05-0136.
Associations of genetic factors with malignant gliomas have been modest. We examined the relationships of human leukocyte antigen (HLA) and related polymorphisms to glioblastoma multiforme in adult Caucasians (non-Hispanic Whites) from the San Francisco Bay area. For 155 glioblastoma multiforme patients and 157 control subjects closely matched by ethnicity, age, and gender, PCR-based techniques resolved alleles at HLA-A, -B, -C, and -DRB1 loci along with short tandem repeat polymorphisms of MICA exon 5 and TNFb. By multivariable logistic regression, B13 and the B07-Cw07 haplotype were positively associated with glioblastoma multiforme (P=0.01 and <0.001, respectively), whereas Cw01 was the only variant showing a negative association (P=0.05). Among glioblastoma multiforme patients, progression to death after diagnosis was slower in those with A32 (relative hazard, 0.45; P<0.01) and faster in those with B55 (relative hazard, 2.27; P<0.01). Thus, both the occurrence and the prognosis of glioblastoma multiforme could be associated with specific but different HLA genotypes. B07 and the B07-Cw*07 haplotype are much more common in Caucasians than other ethnic groups in the U.S., which may partially explain the higher incidence of glioblastoma multiforme in Caucasians.
遗传因素与恶性胶质瘤之间的关联并不显著。我们研究了人类白细胞抗原（HLA）及相关多态性与来自旧金山湾区的成年白种人（非西班牙裔白人）多形性胶质母细胞瘤之间的关系。对于155例多形性胶质母细胞瘤患者和157例在种族、年龄和性别上紧密匹配的对照受试者，基于聚合酶链反应的技术解析了HLA-A、-B、-C和-DRB1基因座的等位基因，以及MICA外显子5和TNFb的短串联重复多态性。通过多变量逻辑回归分析，B13和B07-Cw07单倍型与多形性胶质母细胞瘤呈正相关（P分别为0.01和<0.001），而Cw01是唯一显示负相关的变体（P = 0.05）。在多形性胶质母细胞瘤患者中，诊断后进展至死亡的速度在携带A32的患者中较慢（相对风险，0.45；P<0.01），而在携带B55的患者中较快（相对风险，2.27；P<0.01）。因此，多形性胶质母细胞瘤的发生和预后可能与特定但不同的HLA基因型有关。B07和B07-Cw*07单倍型在白种人中比在美国的其他种族群体中更为常见，这可能部分解释了白种人中多形性胶质母细胞瘤发病率较高的原因。
