Jordan Susan J, Webb Penelope M, Green Adèle C
Cancer and Population Studies Group, Queensland Institute of Medical Research, PO Royal Brisbane Hospital, 4029 Herston, Queensland, and School of Population Health, University of Queensland, Brisbane, Australia.
Cancer Epidemiol Biomarkers Prev. 2005 Aug;14(8):2045-8. doi: 10.1158/1055-9965.EPI-05-0085.
We hypothesized that the hormonal changes of adolescence influence ovarian cancer risk particularly in younger women. We investigated this possibility by examining the relationship between ovarian cancer and adult height and age at menarche as both factors reflect pubertal hormonal levels.
Participants were a population-based sample of women with incident ovarian cancer (n=794) and control women randomly selected from the Australian Electoral Roll (n=855). The women provided comprehensive reproductive and lifestyle data during a standard interview.
Although neither height nor age at menarche was significantly related to the risk of ovarian cancer overall, increasing height was associated with increasing risk of the subgroup of mucinous borderline ovarian cancer (odds ratio, 5.3; 95% confidence interval, 1.5-19.1 for women>or=175 cm compared with women <160 cm, Ptrend=0.02). Similarly, later age at menarche was associated with increasing risk of mucinous borderline cancers (odds ratio, 3.8; 95% confidence interval, 1.3-11.4 for those with age at menarche>or=14 years compared with those <12 years, Ptrend=0.003). Women with mucinous borderline cancers were significantly younger than the women diagnosed with invasive cancers (mean 44 versus 57 years; P<0.0001).
Development of mucinous borderline ovarian cancers, predominantly diagnosed in women ages under 50 years, seems to be associated with age at menarche and attained adult height. These results are consistent with our original hypothesis that pubertal levels of reproductive hormones and insulin-like growth factor-I influence ovarian cancer risk in younger women.
我们推测青春期的激素变化会影响卵巢癌风险，尤其是在年轻女性中。我们通过研究卵巢癌与成年身高及初潮年龄之间的关系来探究这种可能性，因为这两个因素均反映青春期激素水平。
参与者为基于人群的新发卵巢癌女性样本（n = 794）以及从澳大利亚选民登记册中随机选取的对照女性（n = 855）。这些女性在标准访谈中提供了全面的生殖和生活方式数据。
尽管总体而言身高和初潮年龄与卵巢癌风险均无显著关联，但身高增加与黏液性交界性卵巢癌亚组风险增加相关（优势比，5.3；95%置信区间，身高≥175 cm的女性与身高<160 cm的女性相比为1.5 - 19.1，P趋势 = 0.02）。同样，初潮年龄较晚与黏液性交界性癌症风险增加相关（优势比，3.8；95%置信区间，初潮年龄≥14岁的女性与<12岁的女性相比为1.3 - 11.4，P趋势 = 0.003）。黏液性交界性癌症女性明显比浸润性癌症女性年轻（平均44岁对57岁；P<0.0001）。
主要在50岁以下女性中诊断出的黏液性交界性卵巢癌的发生似乎与初潮年龄和成年身高有关。这些结果与我们最初的假设一致，即青春期生殖激素和胰岛素样生长因子 - I水平会影响年轻女性的卵巢癌风险。
