Jordan Susan J, Green Adèle C, Nagle Christina M, Olsen Catherine M, Whiteman David C, Webb Penelope M
School of Population Health, University of Queensland, Public Health Building, Herston Road, Herston, QLD 4006, Australia.
Am J Epidemiol. 2009 Sep 1;170(5):607-14. doi: 10.1093/aje/kwp185. Epub 2009 Jul 28.
Women with higher parity have a lower risk of ovarian cancer possibly because of pregnancy hormones, but the specific effect of different pregnancy hormones on ovarian cancer risk is not clear. Some clarification might be gained by considering situations where hormone levels vary between pregnancies. Study participants from an Australian population-based, case-control study of epithelial ovarian cancer (2001-2005) completed a reproductive/lifestyle questionnaire. The authors included 1,203 cases and 1,286 controls with at least 1 birth and, using multiple logistic regression, calculated odds ratios and 95% confidence intervals to investigate the effects of pregnancy-related factors on cancer risk. Women who had 1 or more preterm births had higher risks of ovarian cancer than those who had only full-term births (odds ratio (OR) = 1.48, 95% confidence interval (CI): 1.02, 2.15). The authors also found that bearing only boys was associated with a 2-fold increased risk of mucinous ovarian cancer (OR = 2.19, 95% CI: 1.15, 4.17). There was no association between multiple pregnancy and ovarian cancer (for any multiple pregnancy vs. only singleton pregnancies: OR = 1.22, 95% CI: 0.74, 2.02). The results suggest that pregnancies associated with differing hormonal milieux have different effects on ovarian cancer risk and that some of these associations may vary with histologic subtype.
生育次数较多的女性患卵巢癌的风险较低，这可能是由于妊娠激素的作用，但不同妊娠激素对卵巢癌风险的具体影响尚不清楚。考虑到不同孕期激素水平存在差异的情况，或许能得到一些解释。来自澳大利亚一项基于人群的上皮性卵巢癌病例对照研究（2001 - 2005年）的参与者完成了一份生殖/生活方式问卷。作者纳入了1203例病例和1286例至少有一次生育经历的对照，运用多因素逻辑回归分析计算优势比和95%置信区间，以研究与妊娠相关的因素对癌症风险的影响。有1次或更多次早产的女性患卵巢癌的风险高于仅足月分娩的女性（优势比（OR）= 1.48，95%置信区间（CI）：1.02，2.15）。作者还发现，只生育男孩与黏液性卵巢癌风险增加2倍相关（OR = 2.19，95% CI：1.15，4.17）。多胎妊娠与卵巢癌之间无关联（任何多胎妊娠与单胎妊娠相比：OR = 1.22，95% CI：0.74，2.02）。结果表明，与不同激素环境相关的妊娠对卵巢癌风险有不同影响，并且其中一些关联可能因组织学亚型而异。
