Adegnika Ayôla A, Breitling Lutz Ph, Agnandji Selidji T, Chai Sanders K, Schütte Daniela, Oyakhirome Sunny, Schwarz Norbert G, Grobusch Martin P, Missinou Michel A, Ramharter Michael, Issifou Saadou, Kremsner Peter G
Medical Research Unit, Albert Schweitzer Hospital, Lambaréné, Gabon.
Am J Trop Med Hyg. 2005 Aug;73(2):263-6.
Pregnant women participating in a longitudinal immuno-epidemiologic survey in Lambaréné, Gabon, and presenting with Plasmodium falciparum parasitemia at monthly blood smear examinations were offered treatment with oral 7-day quinine monotherapy according to national health guidelines. A total of 50 pregnant women were offered 7-day oral quinine sulfate 10 mg/kg thrice daily. Clinical examinations and laboratory tests were performed on Days 28 and 56 to assess the effectiveness of this standard regimen. By Day 28, the effectiveness of the 7-day quinine regimen was 60% (95% confidence interval: 46-72%). We conclude that a 7-day course of quinine has a poor effectiveness and that alternative treatment regimens for malaria in pregnant women should be assessed.
参与加蓬兰巴雷内一项纵向免疫流行病学调查的孕妇，在每月的血涂片检查中出现恶性疟原虫血症时，根据国家卫生指南接受为期7天的口服奎宁单药治疗。共有50名孕妇接受了每日三次、每次10mg/kg硫酸奎宁的7天口服治疗。在第28天和第56天进行临床检查和实验室测试，以评估该标准治疗方案的有效性。到第28天，7天奎宁治疗方案的有效性为60%（95%置信区间：46-72%）。我们得出结论，7天疗程的奎宁有效性较差，应评估孕妇疟疾的替代治疗方案。
