Adam I, Ibrahim M H, A/elbasit I A, Elbashir M I
New Halfa Hospital, New Halfa, Sudan.
East Mediterr Health J. 2004 Jul-Sep;10(4-5):554-9.
Pregnant Sudanese women who presented at a hospital in eastern Sudan with chloroquine-resistant falciparum malaria were randomly allocated to one of two quinine regimens: low-dose (10 mg/kg 2 times/day) (18 patients) or standard (10 mg/kg 3 times/day) (24 patients). Treatment was for 7 days and follow-up for 28 days. Significantly fewer patients in the low-dose group reported vomiting and abdominal pain than the standard regimen group. Hypoglycaemia, preterm labour and recrudescence were slightly but not significantly higher in patients in the standard group than low-dose group. There were no significant differences between the groups in the mean time from admission to remission of fever and parasite clearance. We tentatively advocate the use of quinine 2 times/day to reduce side-effects and improve compliance.
低剂量组（10毫克/千克，每日2次）（18例患者）或标准剂量组（10毫克/千克，每日3次）（24例患者）。治疗为期7天，随访28天。低剂量组报告呕吐和腹痛的患者明显少于标准治疗方案组。标准组患者的低血糖、早产和复发率略高于低剂量组，但差异无统计学意义。两组在从入院到发热缓解和寄生虫清除的平均时间上无显著差异。我们初步主张每日使用2次奎宁以减少副作用并提高依从性。
