[白细胞破碎性血管炎作为丙硫氧嘧啶的不良反应。一例报告]
[Leukocytoclastic vasculitis as an adverse effect of propylthiouracil. A case report].
作者信息
Cortés-Guzmán José Santiago, Veloza Karen T, Domínguez Juan D, Pinzón-Tovar Alejandro
机构信息
Epidemiólogo, residente de tercer año, posgrado de Medicina Interna, Facultad de Salud, Universidad Surcolombiana, Departamento de Medicina Interna, Hospital Universitario Hernando Moncaleano Perdomo, Neiva, Huila, Colombia.
Estudiante de Medicina, Programa de Medicina, Facultad de Salud, Universidad Surcolombiana, Neiva, Huila, Colombia.
出版信息
Rev Alerg Mex. 2023 May 24;70(1):51-54. doi: 10.29262/ram.v70i1.1210.
BACKGROUND
The most common cause of hyperthyroidism is Graves' disease. Propylthiouracil (PTU) is one of the drugs used to treat this disease. Leukocytoclastic vasculitis is described among dermatologic adverse effects of PTU.
CASE REPORT
A 18-year-old woman, allergic to methimazole, developed a vasculitis associated to ANCAs with characteristics of leukocytoclastic vasculitis, associated to PTU treatment. She did not present systemic involvement. PTU treatment was suspended. Two months later, the skin lesions had almost completely resolved.
CONCLUSIONS
Leukocytoclastic vasculitis should be considered in the spectrum of complications caused by the consumption of propylthiouracil. The lesions can manifest over time, from a few weeks to years after taking the drug. When there is no systemic involvement, propylthiouracil suspension is sufficient to cure the disease.
背景
甲状腺功能亢进最常见的病因是格雷夫斯病。丙硫氧嘧啶（PTU）是用于治疗该疾病的药物之一。白细胞破碎性血管炎被描述为PTU的皮肤不良反应之一。
病例报告
一名18岁对甲巯咪唑过敏的女性，出现了与抗中性粒细胞胞浆抗体（ANCA）相关的血管炎，具有白细胞破碎性血管炎的特征，与PTU治疗有关。她未出现全身受累情况。PTU治疗被暂停。两个月后，皮肤病变几乎完全消退。
结论
在丙硫氧嘧啶使用引起的并发症范围内应考虑白细胞破碎性血管炎。病变可在服药后数周甚至数年出现。当无全身受累时，停用丙硫氧嘧啶足以治愈该疾病。
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