Malkov Andrei V, Bourhani Zaïnaba, Kocovský Pavel
Department of Chemistry, WestChem, Joseph Black Building, University of Glasgow, Glasgow G12 8QQ, Scotland, UK.
Org Biomol Chem. 2005 Sep 7;3(17):3194-200. doi: 10.1039/b505324b. Epub 2005 Jul 27.
New sulfonamide-derived hydroxamic acids have been developed as chiral ligands for the V-catalysed asymmetric epoxidation, showing high reactivity at subzero temperatures and moderate to good enantioselectivity. The strong accelerating effect exhibited by the ligands of this type can be attributed to the sulfonamide functionality. A range of cinnamyl type allylic alcohols were epoxidised with up to 74% ee.
新型磺酰胺衍生的异羟肟酸已被开发用作钒催化不对称环氧化反应的手性配体，在零下温度下显示出高反应活性以及中等至良好的对映选择性。这类配体所表现出的强烈加速效应可归因于磺酰胺官能团。一系列肉桂基型烯丙醇被环氧化，对映体过量值高达74%。
