School of Pharmacy, East China University of Science and Technology, 130 Mei-Long Road, Shanghai 200237, China.
Chem Commun (Camb). 2014 Feb 7;50(10):1231-3. doi: 10.1039/c3cc47921h.
An enantioselective epoxidation of tryptophols followed by an intramolecular epoxide opening reaction was realized by chiral vanadium catalysts derived from C2 symmetric bis-hydroxamic acid (BHA) ligands. 3a-Hydroxyfuroindoline derivatives with up to 89% yield and 90% ee were obtained under mild reaction conditions.
手性钒催化剂衍生自 C2 对称双羟肟酸（BHA）配体，实现了色氨酸的对映选择性环氧化反应，随后进行了分子内环氧化开环反应。在温和的反应条件下，以高达 89%的收率和 90%的对映选择性得到了 3a-羟基呋喃并吲哚啉衍生物。
