Lelbach Adám, Muzes Györgyi, Feheŕ János
Semmelweis Egyetem, Altalános Orvostudományi Kar, Il. Belgyógyászati Klinika, Budapest.
Orv Hetil. 2004 Nov 14;145(46):2329-34.
Molecular mechanisms of cancer cachexia. Cancer cachexia is a complex, multifactorial syndrome characterised by a critical weight loss, anorexia, asthenia and anaemia. Most of the patients with advanced cancer suffer from cancer cachexia. The cachectic state is closely associated with progressive expansion of the tumour and leads to a malnutrition status due to the induction of anorexia and decreased food intake. In addition, the competition for nutrients between the tumour and the host leads to malnutrition state, too, which promotes severe metabolic disturbances in the host, including hypermetabolism which leads to an increased energetic inefficiency. Although, the search for the cachectic factors has a long history, we are still far away from knowing the complete answer. The main aim of the present paper is to summarise the different catabolic mediators involved in cancer cachexia. Better understanding of the pathomechanism of cancer cachexia can lead to the discovery of new, effective strategies of the therapy for the future.
癌症恶病质的分子机制。癌症恶病质是一种复杂的多因素综合征，其特征为严重体重减轻、厌食、乏力和贫血。大多数晚期癌症患者患有癌症恶病质。恶病质状态与肿瘤的进行性扩展密切相关，并由于厌食和食物摄入量减少而导致营养不良状态。此外，肿瘤与宿主之间对营养物质的竞争也会导致营养不良状态，这会促使宿主出现严重的代谢紊乱，包括导致能量利用效率增加的高代谢。尽管对恶病质因素的研究历史悠久，但我们距离知晓完整答案仍有很大差距。本文的主要目的是总结参与癌症恶病质的不同分解代谢介质。更好地理解癌症恶病质的发病机制有助于发现未来新的有效治疗策略。
