Argilés Josep M, Busquets Sílvia, López-Soriano Francisco J
Departament de Bioquímica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, Barcelona, Spain.
Cancer Treat Res. 2006;130:199-217. doi: 10.1007/0-387-26283-0_9.
The cachexia syndrome, characterized by a marked weight loss, anorexia, asthenia and anaemia, is invariably associated with the growth of a tumour and leads to a malnutrition status caused by the induction of anorexia or decreased food intake. In addition, the competition for nutrients between the tumour and the host results in a state of accelerated catabolism, which promotes severe metabolic disturbances in the patient. The search for the cachectic factor(s) started a long time ago, and many scientific and economic efforts have been devoted to its discovery, but we are still a long way from a complete answer. The present review aims to evaluate the different molecular mechanisms and catabolic mediators (both humoural and tumoural) that are involved in cancer cachexia and to discuss their potential as targets for future clinical investigations.
恶病质综合征的特征是显著体重减轻、厌食、乏力和贫血，它总是与肿瘤生长相关，并导致由厌食或食物摄入量减少引起的营养不良状态。此外，肿瘤与宿主之间对营养物质的竞争导致分解代谢加速状态，这会促使患者出现严重的代谢紊乱。对恶病质因子的探索早在很久以前就开始了，并且已经投入了许多科学和经济方面的努力来发现它，但我们距离找到完整答案仍有很长的路要走。本综述旨在评估参与癌症恶病质的不同分子机制和分解代谢介质（包括体液性和肿瘤性），并讨论它们作为未来临床研究靶点的潜力。
