de Zoysa Janak Rashme, Topham Peter Stewart
Department of Renal Medicine, Auckland City Hospital, Auckland, New Zealand.
Nephrology (Carlton). 2005 Aug;10(4):362-7. doi: 10.1111/j.1440-1797.2005.00401.x.
The podocyte is a highly specialized cell that plays a key role in regulating the glomerular filtration barrier. A number of advances have been made in recent years, linked to the discovery of single-gene defects in hereditary glomerular disease, which highlight the role of this cell in preventing proteinuria. This article reviews the molecular biology of the podocyte, focusing on known genetic abnormalities.
足细胞是一种高度特化的细胞，在调节肾小球滤过屏障中起关键作用。近年来，随着遗传性肾小球疾病中单基因缺陷的发现取得了一些进展，这些发现突出了该细胞在预防蛋白尿中的作用。本文综述了足细胞的分子生物学，重点关注已知的基因异常。
