入住康复医院的巴西年轻和老年中风患者的缺血性中风亚型与血栓形成倾向

Ischemic stroke subtypes and thrombophilia in young and elderly Brazilian stroke patients admitted to a rehabilitation hospital.

作者信息

Carod-Artal Francisco Javier, Nunes Simone Vilela, Portugal Dalton, Silva Tania Virginia Fernandes, Vargas Antonio Pedro

机构信息

Neurology Department, The Sarah Network of Rehabilitation Hospitals, Sarah Hospital, Brasilia, DF, Brazil.

出版信息

Stroke. 2005 Sep;36(9):2012-4. doi: 10.1161/01.STR.0000177881.34840.cf. Epub 2005 Aug 18.

DOI:10.1161/01.STR.0000177881.34840.cf

PMID:16109904

Abstract

BACKGROUND AND PURPOSE

We sought to examine ischemic stroke subtypes and prevalence of thrombophilia in Brazilian stroke patients.

METHOD

A total of 130 consecutive young and 200 elderly stroke patients were studied.

RESULTS

Prevalence of thrombophilia was, respectively: protein S deficiency (11.5% versus 5.5%), protein C deficiency (0.76% versus 1%), resistance to activated protein C (2.3% versus 3.5%), mutation in V Leiden factor (1.5% versus 2%), antithrombin III deficiency (0% versus 0%), lupus anticoagulant (0% versus 0.5%), anticardiolipin antibodies (3% versus 10%; P=0.01), hyperhomocysteinemia (31.5% versus 53.5%; P=0.0001), mutation of the MTHFR gene in homocigosis (10% versus 5%), and heterocigosis (27.6% versus 41.9%; P=0.01).

CONCLUSIONS

Prothrombotic conditions were more frequent in stroke of undetermined cause.

摘要

背景与目的

我们试图研究巴西中风患者的缺血性中风亚型及血栓形成倾向的患病率。

方法

共研究了130例连续的年轻中风患者和200例老年中风患者。

结果

血栓形成倾向的患病率分别为：蛋白S缺乏（11.5%对5.5%）、蛋白C缺乏（0.76%对1%）、对活化蛋白C的抵抗（2.3%对3.5%）、V莱顿因子突变（1.5%对2%）、抗凝血酶III缺乏（0%对0%）、狼疮抗凝物（0%对0.5%）、抗心磷脂抗体（3%对10%；P=0.01）、高同型半胱氨酸血症（31.5%对53.5%；P=0.0001）、纯合子MTHFR基因突变（10%对5%）以及杂合子（27.6%对41.9%；P=0.01）。