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蛋白S缺乏症:年轻人反复发生缺血性中风。

Protein S deficiency: Recurrent ischemic stroke in young.

作者信息

Hooda Amit, Khandelwal P D, Saxena Puneet

机构信息

Department of Medicine, SMS Medical College and Hospital, Jaipur, Rajasthan, India.

出版信息

Ann Indian Acad Neurol. 2009 Jul;12(3):183-4. doi: 10.4103/0972-2327.56319.

DOI:10.4103/0972-2327.56319
PMID:20174500
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2824936/
Abstract

Stroke in young poses a major health problem. Thrombophilic factors have been implicated in 4-8% of the young strokes worldwide. Protein S deficiency is a rare cause of recurrent ischemic stroke in young population. Only a few sporadic cases have been described in the literature. We are reporting a case of protein S deficiency-related recurrent ischemic stroke in a 16-year-old girl. Early diagnosis and targeted approach can help such patients to prevent recurrent thrombotic episodes.

摘要

年轻人中风是一个重大的健康问题。全球范围内,4%至8%的年轻中风患者与血栓形成倾向因素有关。蛋白S缺乏是年轻人群复发性缺血性中风的罕见病因。文献中仅描述了少数散发病例。我们报告一例16岁女孩因蛋白S缺乏导致的复发性缺血性中风病例。早期诊断和针对性治疗有助于此类患者预防血栓复发事件。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d6e/2824936/8ef1e38b985e/AIAN-12-183-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d6e/2824936/8ef1e38b985e/AIAN-12-183-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d6e/2824936/8ef1e38b985e/AIAN-12-183-g001.jpg

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本文引用的文献

1
Ischemic stroke subtypes and thrombophilia in young and elderly Brazilian stroke patients admitted to a rehabilitation hospital.入住康复医院的巴西年轻和老年中风患者的缺血性中风亚型与血栓形成倾向
Stroke. 2005 Sep;36(9):2012-4. doi: 10.1161/01.STR.0000177881.34840.cf. Epub 2005 Aug 18.
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Antithrombin, protein C and protein S levels in 127 consecutive young adults with ischemic stroke.127例连续性青年缺血性脑卒中患者的抗凝血酶、蛋白C和蛋白S水平
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BMJ Case Rep. 2012 Jul 27;2012:bcr2012006496. doi: 10.1136/bcr-2012-006496.
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青年急性脑缺血患者的凝血功能障碍
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Stroke. 1993 Feb;24(2):224-7. doi: 10.1161/01.str.24.2.224.
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Stroke. 1970 Nov-Dec;1(6):477-81. doi: 10.1161/01.str.1.6.477.
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Thromb Haemost. 1989 Nov 24;62(3):1040.
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Thromb Haemost. 1989 Feb 28;61(1):144-7.
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[Influence of protein S deficiency on the arterial thrombosis risk].[蛋白S缺乏对动脉血栓形成风险的影响]
Presse Med. 1991 Jun 8;20(22):1023-7.