Lee Heon-Jeong, Sung Seung-Mo, Han Chang-Su, Kim Yong-Ku, Kim Seung-Hyun, Lee Min-Soo, Joe Sook-Haeng, Jung In-Kwa, Kim Leen
Department of Psychiatry, Anam Hospital, Korea University College of Medicine, Anam-Dong, Seongbuk-Gu, Seoul 136-705, Korea.
Neuropsychobiology. 2005;52(3):135-9. doi: 10.1159/000087559. Epub 2005 Aug 17.
This study investigated the relationship between G-protein beta(3) subunit (GNB3) C825T polymorphism and seasonal variation in 189 young male college students. The subjects were genotyped for C825T and were evaluated by the Seasonality Pattern Assessment Questionnaire. The Global Seasonality Score (GSS) between the three genotypes revealed a marginal difference. The heterozygotes showed significantly higher seasonal variations in GSS than the homozygotes. The prevalence of heterozygotes tended to be higher in seasonals compared with normal subjects, although it was not statistically significant. These results suggest that GNB3 C825T polymorphism tends to be related to seasonal variation in mood and behavior in the normal population.
本研究调查了189名年轻男性大学生中G蛋白β(3)亚基（GNB3）C825T多态性与季节变化之间的关系。对受试者进行C825T基因分型，并通过季节性模式评估问卷进行评估。三种基因型之间的全球季节性评分（GSS）显示出微小差异。杂合子的GSS季节性变化显著高于纯合子。与正常受试者相比，季节性人群中杂合子的患病率往往更高，尽管差异无统计学意义。这些结果表明，GNB3 C825T多态性可能与正常人群情绪和行为的季节性变化有关。
