Lee Heon-Jeong, Sung Seung-Mo, Lim Se-Won, Paik Jong-Woo
Department of Psychiatry, Anam Hospital, Korea University College of Medicine, Anam-Dong, Seongbuk-Gu, Seoul 136-705, Korea.
J Affect Disord. 2006 Oct;95(1-3):145-8. doi: 10.1016/j.jad.2006.05.001. Epub 2006 Jun 9.
Seasonal affective disorder and seasonal rhythms in mood and behavior (seasonality) have been reported to be associated with serotonergic system. In this study we investigated the relationship between the serotonin 2A receptor (5HTR2A) -1438 A/G polymorphism and seasonal variation in a young Korean healthy population.
297 young Korean medical students were recruited for this study. They were genotyped for the 5HTR2A -1438 A/G polymorphism and evaluated the seasonal variation in mood and behavior by the Seasonality Pattern Assessment Questionnaire (SPAQ).
The Global Seasonality Score of the SPAQ among three genotypes were not different. However, the comparison between seasonals and non-seasonals showed significant difference in the genotype distribution. The winter-type seasonals showed a significantly higher frequency of the 5HTR2A -1438 A allele compared with non-seasonals (chi2 = 6.80, p = 0.009; OR = 1.79; 95% CI, 1.15-2.78).
These results suggest that the 5HTR2A -1438 A/G polymorphism is possibly related to seasonality in the Korean population.
季节性情感障碍以及情绪和行为的季节性节律（季节性）据报道与血清素能系统有关。在本研究中，我们调查了韩国年轻健康人群中血清素2A受体（5HTR2A）-1438 A/G多态性与季节变化之间的关系。
招募了297名韩国年轻医学生参与本研究。对他们进行5HTR2A -1438 A/G多态性基因分型，并通过季节性模式评估问卷（SPAQ）评估情绪和行为的季节性变化。
三种基因型之间SPAQ的总体季节性得分没有差异。然而，季节性人群和非季节性人群之间的比较显示基因型分布存在显著差异。与非季节性人群相比，冬季型季节性人群中5HTR2A -1438 A等位基因的频率显著更高（卡方=6.80，p = 0.009；OR = 1.79；95% CI，1.15 - 2.78）。
这些结果表明5HTR2A -1438 A/G多态性可能与韩国人群的季节性有关。
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