Ardekani Babak A, Bappal Arthika, D'Angelo Debra, Ashtari Manzar, Lencz Todd, Szeszko Philip R, Butler Pamela D, Javitt Daniel C, Lim Kelvin O, Hrabe Jan, Nierenberg Jay, Branch Craig A, Hoptman Matthew J
Center for Advanced Brain Imaging, Nathan S. Kline Institute for Psychiatric Research, Orangeburg, New York, USA.
Neuroreport. 2005 Sep 8;16(13):1455-9. doi: 10.1097/01.wnr.0000177001.27569.06.
Loss of cortical gray matter is accompanied by a commensurate increase in the sulcal and intraventricular cerebrospinal fluid volume. On diffusion-weighted magnetic resonance imaging, this would be reflected as a higher apparent diffusion coefficient in affected brain regions. On the basis of the above premise, we suggest that the apparent diffusion coefficient may be used as a surrogate marker for the assessment of regional brain volume deficits. We demonstrate this approach by voxelwise analysis of registered apparent diffusion coefficient images from a group of 15 patients with schizophrenia and 15 age-matched healthy controls. We found widespread regional apparent diffusion coefficient increases in patients. Affected areas included the bilateral insular cortex, hippocampus, temporal lobe, and occipital areas. These results largely concur with previous findings of cortical volume deficits in schizophrenia.
皮质灰质的减少伴随着脑沟和脑室内脑脊液体积的相应增加。在扩散加权磁共振成像上，这将表现为受影响脑区的表观扩散系数升高。基于上述前提，我们认为表观扩散系数可用作评估局部脑容量缺损的替代标志物。我们通过对一组15例精神分裂症患者和15例年龄匹配的健康对照者的配准表观扩散系数图像进行体素分析来证明这一方法。我们发现患者中存在广泛的局部表观扩散系数升高。受影响的区域包括双侧岛叶皮质、海马体、颞叶和枕叶区域。这些结果在很大程度上与先前关于精神分裂症皮质容量缺损的研究结果一致。
