Hoptman Matthew J, Ardekani Babak A, Butler Pamela D, Nierenberg Jay, Javitt Daniel C, Lim Kelvin O
Division of Clinical Research, Nathan Kline Institute, 140 Old Orangeburg Rd, Orangeburg, NY 10962, USA.
Neuroreport. 2004 Nov 15;15(16):2467-70. doi: 10.1097/00001756-200411150-00007.
Compromised white matter (WM) integrity in inferior frontal WM has been related to impulsivity in men with schizophrenia. However, these relationships may be more widespread. Fractional anisotropy (FA) derived from diffusion tensor imaging of 25 men with schizophrenia was transformed into Talairach space. Correlations between FA and impulsiveness were examined on a voxelwise basis. We found negative correlations between FA and impulsivity in inferior frontal WM, anterior cingulate, caudate, insula, and inferior parietal lobule. Positive correlations were obtained in the left postcentral gyrus, right superior/middle temporal gyrus, and bilateral fusiform gyrus. These areas may comprise a fronto-temporo-limbic circuit that modulates impulsivity. The voxelwise correlation method can serve as a hypothesis-generation method for relating target behaviors to their underlying neural networks.
额叶下部白质（WM）完整性受损与精神分裂症男性的冲动性有关。然而，这些关系可能更为广泛。对25名精神分裂症男性进行扩散张量成像得出的分数各向异性（FA）被转换到Talairach空间。在体素水平上检查了FA与冲动性之间的相关性。我们发现额叶下部WM、前扣带回、尾状核、岛叶和顶下小叶中FA与冲动性呈负相关。在左侧中央后回、右侧颞上/中回和双侧梭状回中获得了正相关。这些区域可能构成一个调节冲动性的额颞边缘回路。体素水平相关方法可作为一种将目标行为与其潜在神经网络联系起来的假设生成方法。
